Description
Product Overview: HGH Fragment 176–191
HGH Fragment 176–191 (GH Frag 176–191) is a synthetic 16-amino acid peptide representing the C-terminal end region of human growth hormone. Engineered specifically to isolate the metabolic and lipolytic domains of native growth hormone, this fragment stimulates adipose cell breakdown without binding to classical growth hormone receptors or triggering systemic IGF-1 elevation, cell proliferation, or hyperglycemia.
Primary Research Applications & Reasons for Study
- Adipose Lipolysis Activation: Upregulating beta-3 adrenergic receptors to drive the enzymatic breakdown of stored triglycerides into free fatty acids.
- Inhibition of Lipogenesis: Blocking key enzymes involved in fatty acid synthesis to suppress new lipid accumulation in white adipose tissue.
- Glycemic Independence: Studying fat metabolism dynamics while avoiding the diabetogenic side effects, glucose intolerance, and insulin resistance associated with full-length hGH.
- Non-Mitogenic Profile: Verifying the absence of IGF-1 upregulation, cellular proliferation, and somatic growth in long-term exposure models.
Expected Research Results & Timeline Metrics
-
Phase 1 / Days 1–7
Free Fatty Acid Mobilization: Initial stimulation of beta-3 adrenergic pathways leading to elevated fatty acid release in acute adipose tissue cultures. -
Phase 2 / Weeks 2–4
Adipose Mass Reduction: Statistically significant reduction in lipid droplet volume and localized fat cell density in animal models. -
Phase 3 / Weeks 4–8
Sustained Lipid Clearing: Continued suppression of lipogenesis and improved metabolic body composition markers with stable baseline serum glucose and insulin levels.
Key Research Benefits
- Targeted Fat Breakdown: Highly selective for lipolysis without affecting surrounding lean muscle tissue or organ mass.
- High Safety Margin: Does not cause hyperglycemia, fluid retention, or systemic growth hormone receptor cross-reactivity.
- Blocks Lipogenesis: Inhibits pre-adipocyte differentiation and prevents secondary lipid storage.
- Potent In Vitro Tool: Ideal standard for comparative metabolic assays against full-length hGH and other lipolytic fragments.
THIS PRODUCT IS INTENDED SOLELY FOR IN VITRO LABORATORY RESEARCH AND EXPERIMENTAL PURPOSES. It is strictly prohibited for human consumption, clinical trials, therapeutic administration, cosmetic use, or veterinary application. This product is not an FDA-approved drug, medical food, or dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease, illness, or medical condition. Any handling, reconstitution, or experimentation involving this chemical compound must be conducted strictly by qualified, trained laboratory professionals utilizing appropriate containment and personal protective equipment in accordance with scientific biosafety standards. Buyers and users assume full liability for compliance with local, state, and federal laws regarding the handling and possession of research compounds.