Description
Product Overview: Selank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed by modifying the naturally occurring immunomodulatory peptide Tuftsin through the addition of a C-terminal Pro-Gly-Pro sequence for enzymatic stabilization. Engineered for neuroprotective, anxiolytic, and immunomodulatory research, Selank influences GABAergic neurotransmission, modulates central monoamine metabolism (serotonin and dopamine turnover), and upregulates Brain-Derived Neurotrophic Factor (BDNF) without causing sedation or physical dependence, serving as a primary model for stress-adaptation and cognitive research.
Primary Research Applications & Reasons for Study
- GABAergic & Allosteric Modulation: Studying non-benzodiazepine modulation of GABA_A receptors to evaluate anxiolytic response pathways without sedation, amnesia, or muscle relaxation.
- BDNF & Neurotrophic Expression: Upregulating BDNF and its receptor TrkB in the hippocampus to evaluate synaptic plasticity, learning retention, and neuronal survival under stress.
- Enkephalin Degradation Inhibition: Blocking enkephalin-degrading enzymes in blood plasma to elevate endogenous enkephalins and stabilize stress-response cascades.
- Immunomodulatory Signaling: Assessing interleukin modulation ($\text{IL-6}$ regulation) and immune system cross-talk via its structural relationship to Tuftsin.
Expected Research Results & Timeline Metrics
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Phase 1 / Hours 1–24
Rapid Anxiolytic Signaling: Immediate modulation of central monoamine levels, acute enkephalinase inhibition, and measurable reduction in stress-induced behavior markers in rodent paradigms. -
Phase 2 / Weeks 1–2
BDNF Elevation & Cognitive Enhancement: Statistically significant upregulation of hippocampal BDNF expression, improved spatial memory acquisition, and stabilized neurotransmitter turnover during chronic stress testing. -
Phase 3 / Weeks 3–6
Sustained Neuro-Immune Adaptation: Normalized cytokine signaling profiles, persistent resistance to stress-induced cognitive impairment, and long-term stabilization of central nervous system parameters without withdrawal effects.
Key Research Benefits
- Non-Sedative Anxiolytic Profile: Reduces anxiety metrics in laboratory models without impairing motor coordination, focus, or cognitive performance.
- Dual Nootropic & Protective Utility: Simultaneously promotes cognitive consolidation via BDNF up-regulation and protects neurons from oxidative stress.
- Enzymatic Resistance: C-terminal Pro-Gly-Pro tripeptide addition extends metabolic stability and half-life in physiological fluid systems.
- Tuftsin-Derived Immunomodulation: Provides a unique research model for studying cross-talk between the central nervous system and immune system pathways.
THIS PRODUCT IS INTENDED SOLELY FOR IN VITRO LABORATORY RESEARCH AND EXPERIMENTAL PURPOSES. It is strictly prohibited for human consumption, clinical trials, therapeutic administration, cosmetic use, or veterinary application. This product is not an FDA-approved drug, medical food, or dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease, illness, or medical condition. Any handling, reconstitution, or experimentation involving this chemical compound must be conducted strictly by qualified, trained laboratory professionals utilizing appropriate containment and personal protective equipment in accordance with scientific biosafety standards. Buyers and users assume full liability for compliance with local, state, and federal laws regarding the handling and possession of research compounds.